If you’re talking about the infectious brain hypothesis, I agree. I’m submitting a manuscript on this topic right now. I wouldn’t say that all mouse studies are pointless though. People just tend to design and/or interpret them poorly due to ignoring limitations. Mouse and human physiology are in fact more dissimilar than the majority of researchers seem to acknowledge.

Yeah, I didn’t read the whole thing but apparently only in 5xFAD mice. I wish they would have also tried it in a Tau model like PS19.

I agree with the general sentiment here but just wanted to clarify that they definitely didn’t “solve protein folding” yet. Alpha fold is a significant improvement in structure prediction and it generated a lot of hype but some of the structures I’ve seen it put out are total nonsense.